Presentation of the IMRB
Created jointly by the Institut National de la Santé et de la Recherche Médicale (INSERM; the French national institute for health and medical research) and the
University of Paris 12 - Val de Marne, the Institut Mondor de Recherche Biomédicale (IMRB) brings together 15 mixed Inserm-University of Paris 12 research teams, under 2 research pole. 
Research pole of Functional regeneration and biotherapicsResearch Pole of Medical genomicsIts 300 collaborators work in three major fields of health research:
the etiology of genetic, metabolic, cancerous or viral diseases; the development of gene and cell-based biotherapies; the development of new pharmacological strategies for therapeutics.Over the last five years, the research teams of the IMRB have authored more than 1400 publications.
The principal assets of the IMRB lie in:
its implantation, at the center of a strong pole for health and clinical research, including three hospitals, a general Clinical Investigation Center dedicated to Biotherapy, a Biological Resource Center, a Surgical Research Center, the cell therapy unit of the French Establishment of the Blood, as well as seven reference centers for rare diseases. access to 5 core technological facilities for genomics, imaging, cell sorting and functional exploration of small animals, as well as three common animal houses (conventional, transgenic and large animal).Additionally, the IMRB actively supports the development of a new immunomonitoring core facility aimed at evaluating new immunological therapies according to international standards.
The IMRB teams are involved in four European projects, and participate in 130 collaborations worldwide, principally with laboratories in Europe and North America.
Expected impact on health/Expected health benefits
One hundred and twenty teaching doctors participate in the teams. Among them are the principal investigators of 21 clinical research protocols corresponding to 5 international multicentric trials and 16 monocentric trials. These programs cover the majority of the research topics of the teams.
Valorizable activities
During the last five years, six teams of the IMRB have obtained 30 patents, for 9 of which a license for exploitation has been granted to companies. The majority of these patents have been obtained in the field of immunology. Inserm-transfert is currently following up 11 research collaboration contracts between the IMRB and private partners.
Private partnership contracts accounted for almost 8% of the total funding of the IMRB in 2006.
Since 2007, a valorization cell has been established at the IMRB, with the help of the Agglomération Plaine Centrale community, the University of Paris 12, and the regional council of the Val-de-Marne.
Procedures to obtain ISO 9001 certification for certain activities of the IMRB have also been started.
Key words
Molecular and cell biology, cardiology, dermatology, genetics, hepatology, immunology, infectious diseases, neurosciences, oncology, pneumology, virology.
Address
Inserm U955- Groupe Hospitalier Universitaire Albert Chenevier - Henri Mondor
51 av du Maréchal de Lattre de Tassigny
94010 Créteil cedex
Tél. : 01 49 81 37 70
Fax. : 01 49 81 39 00
institutmondor@inserm.fr
Addresses of the Web site of the IMRB
Version française
News of IMRB
The international science film festival PARISCIENCE, from 7 to 11 october 2009, at Museum national d'Histoire naturelle, Jardin des Plantes in Paris.
Alain Berdeaux's intervention (IMRB, team 3) after the broadcasting of the film "" Baby boomers, à l'assaut du Mont Méra" (Events)
Partners
Key figures
Research teams: 15
Members: 300 collaborators (140 tenured researchers, 60 engineers/technicians, 100 doctoral and postdoctoral fellows)
Laboratory surface area: 5 500 m2
Funding other than salaries: 3.5 M€/year
International collaborations: 130
European projets: 4
Publications : 1 400 articles and reviews in 5 years
Patents: 30, including 9 under exploitation licenses
Publications
Lantieri L, Meningaud JP, Grimbert P, Bellivier F, Lefaucheur JP, Ortonne N, Benjoar MD, Lang P, Wolkenstein P,. (link towards the team) Repair of the lower and middle parts of the face by composite tissue allotransplantation in a patient with massive plexiform neurofibroma: a 1-year follow-up study (2008) Lancet, 372, 639-645.
Mercat A, Richard JCM, Vielle B, Jaber S, Osman D, Diehl JL, Lefrant JY, Prat G, Richecoeur J, Nieszkowska A, Gervais C, Baudot J, Bouadma L, Brochard L,. (link towards the team) Positive end-expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome - A randomized controlled trial (2008) JAMA-J. Am. Med. Assoc., 299, 646-655.
Szatmari P, Paterson AD, Zwaigenbaum L, Roberts W, and al. (link towards the team)
Mapping autism risk loci using genetic linkage and chromosomal rearrangements.
Nat Genet. 2007 Mar;39(3):319-28. Epub 2007 Feb 18.
Durand CM, Betancur C, Boeckers TM, Bockmann J, and al. (link towards the team)
Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders.
Nat Genet. 2007 Jan;39(1):25-7. Epub 2006 Dec 17.
Stransky N, Vallot C, Reyal F, Bernard-Pierrot I, de Medina SG, Segraves R, de Rycke Y, Elvin P, Cassidy A, Spraggon C, Graham A, Southgate J, Asselain B, Allory Y, Abbou CC, Albertson DG, Thiery JP, Chopin DK, Pinkel D, Radvanyi F. (link towards the team)
Regional copy number-independent deregulation of transcription in cancer.
Nat Genet. 2006 Dec;38(12):1386-96. Epub 2006 Nov 12.
Teixeira-Clerc F, Julien B, Grenard P, Tran Van Nhieu J, Deveaux V, Li L, Serriere-Lanneau V, Ledent C, Mallat A, Lotersztajn S. (link towards the team)
CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis.
Nat Med. 2006 Jun;12(6):671-6. Epub 2006 May 21.
Giarratana MC, Kobari L, Lapillonne H, Chalmers D, Kiger L, Cynober T, Marden MC, Wajcman H, Douay L. (link towards the team)
Ex vivo generation of fully mature human red blood cells from hematopoietic stem cells.
Nat Biotechnol. 2005 Jan;23(1):69-74. Epub 2004 Dec 26.
Challine D, Pellegrin B, Bouvier-Alias M, Rigot P, Laperche L, Pawlotsky JM. (link towards the team)
HIV and hepatitis C virus RNA in seronegative organ and tissue donors.
Lancet. 2004 Oct 30-Nov 5;364(9445):1611-2.
